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PD‐L1 methylation regulates PD‐L1 expression and is associated with melanoma survival

21 Oct 2018

Abstract excerpt

The aim of this study is to determine the significance of programmed death ligand 1 (PD-L1 or CD274) methylation in relation to PD-L1 expression and survival in melanoma. Despite the clinical importance of therapies targeting the PD-1/PD-L1 immune checkpoint in melanoma, factors regulating PD-L1 expression, including epigenetic mechanisms, are not completely understood. In this study, we examined PD-L1 promoter...

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PMID: 30343532
DOI: 10.1111/pcmr.12745

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