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Article

Dicer-2 mutations in Aedes aegypti cells lead to a diminished antiviral function against Rift Valley fever virus and Bunyamwera virus infection.

The Journal of general virology - 1 Nov 2024

Dornbusch Susann, Reuter Melinda, Parry Rhys H, Stern Michael, Becker Stefanie C, Schnettler Esther

Abstract excerpt

Mosquitoes are known to transmit different arthropod-borne viruses belonging to various virus families. The exogenous small interfering RNA pathway plays an important role in the mosquito defence against such virus infections, with Dicer-2 (Dcr2) as one of the key proteins that initiates the cleavage of viral dsRNAs into 21 nt long virus-derived small interfering RNAs. Previous data identified the importance of...

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Aedes
Cell Line
Insect Proteins
Mutation
Ribonuclease III

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Small Interfering

Virus Replication

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Identifiers

PMID: 39508739
DOI: 10.1099/jgv.0.002046
PMCID: PMC11542633

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