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Article

COVID-19 vaccination shifts neutrophils toward a mixed activated and regulatory phenotype in patients with severe disease.

Molecular biology reports - 11 Apr 2026

de Oliveira Yrna Lorena M, de S Resende Ayane, de Franca Mariana N F, Santos Camilla Natália O, Magalhães Lucas S, Correa Cristiane B, Dos S Almeida Priscila L, da Silva Angela Maria, Lipscomb Michael W, de Moura Tatiana R

Abstract excerpt

BACKGROUND: Dysregulation of the innate immune response to SARS-CoV-2 has been linked to poor outcomes in COVID-19. Neutrophils are key players in this response, displaying distinct functional profiles associated with disease severity. This study investigates how neutrophil phenotypes, and their mediators are modulated in severe COVID-19 following vaccination. METHODS AND RESULTS: We conducted an observational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41964802
DOI: 10.1007/s11033-026-11778-y
PMCID: PMC13070084

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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