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Article

The genetic basis of the immune response to SARS-CoV-2 infection and vaccination in the Italian municipality of Vo'.

Frontiers in immunology - 1 Jan 2026

Zapparoli Ettore, Lavezzo Enrico, Tonnelé Hélène, Simeoni Fabio, Guo Jing, Walter Klaudia, Tascini Anna Sofia, Sharapov Sodbo, Elyanow Rebecca, Bado Martina, Mazzotti Giorgia, Penkov Dmitry, Morelli Marco J, Lazarevic Dejan, Pirastu Nicola, Soranzo Nicole, Kirsch Ilan R, Crisanti Andrea, Toppo Stefano, Provero Paolo, Tonon Giovanni

Abstract excerpt

Introduction: It is becoming increasingly evident that SARS-CoV-2 infection is here to stay. Therefore, understanding whether genetic variants may impact the response to the virus or vaccination is crucial. Studies on the genetic determinants of immune responses to SARS-CoV-2 have been limited by the scarcity of genetically homogenous populations and longitudinal designs that assess responses to both infection...

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Identifiers

PMID: 41869329
DOI: 10.3389/fimmu.2026.1718158
PMCID: PMC13002426

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