Article
Genome-wide association studies of response and side effects to the BNT162b2 vaccine in Italian healthcare workers: Increased antibody levels and side effects in carriers of the HLA-A*03:01 allele.
HLA - 1 Dec 2023
Magri Chiara, Marchina Eleonora, Sansone Emanuele, D'Adamo Adamo Pio, Cappellani Stefania, Bonfanti Carlo, Terlenghi Luigina, Biasiotto Giorgio, Zanella Isabella, Sala Emma, Caruso Arnaldo, Lombardo Massimo, Gasparini Paolo, De Palma Giuseppe, Gennarelli Massimo
Abstract excerpt
The remarkable variability of response to vaccines against SARS-CoV-2 is apparent. The present study aims to estimate the extent to which the host genetic background contributes to this variability in terms of immune response and side effects following the administration of the BNT162b2 vaccine. We carried out a genome wide association study (GWAS) by genotyping 873 Italian healthcare workers who underwent...
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