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Article

Analyses of plasma multi-omic data across ancestries identify novel pathways implicated in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Yang Chengran, Timsina Jigyasha, Liu Menghan, Budde John, Kohlfeld Pat, Brock William, Morris John C, Holtzman David M, Sung Yun Ju, Cruchaga Carlos

Abstract excerpt

INTRODUCTION: Few genetic studies on Alzheimer's disease (AD) have incorporated multiple ancestries and omic datasets to pinpoint actionable AD risk effectors for each ancestry. METHODS: Here, we first performed genetic colocalization between molecular phenotypes (proteomics and metabolomics) from two ancestral groups (European [EUR] and African [AFR]) and the two largest EUR AD genome-wide association studies....

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Identifiers

PMID: 41653107
DOI: 10.1002/alz.71164
PMCID: PMC12882555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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