Article
Mutations with prognostic value in uveal melanoma: analytical study of variants detected by targeted next-generation sequencing.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie - 1 Jun 2026
Pérez-Pérez Manuel, de Sola-Llamas Carmen García, Agostino Alessandro, Ruvolo Michael, Vilches-Arenas Angel, Relimpio-López M Isabel, Macías-García Laura, De Miguel-Rodríguez Manuel, Umbria-Jimenez Sebastian, García-Escudero Antonio, Idoate Miguel A, Ríos-Martín Juan J
Abstract excerpt
OBJECTIVE: To identify genetic variants with prognostic value in uveal melanoma (UM) using targeted next-generation sequencing (NGS) and evaluate their association with metastasis and histologic subtype. DESIGN: A retrospective observational study. METHODS: Targeted NGS was performed on tumour samples from 69 patients with choroidal melanoma treated by enucleation. Histopathological features and clinical outcomes...
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