Next-generation sequencing of uveal melanoma with clinical and histological correlations: Prognostic value of new mutations in the PI3K/AKT/mTOR pathway.

doi:10.1111/ceo.14302

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Article

Next-generation sequencing of uveal melanoma with clinical and histological correlations: Prognostic value of new mutations in the PI3K/AKT/mTOR pathway.

Clinical & experimental ophthalmology - 1 Nov 2023

Pérez-Pérez Manuel, Agostino Alessandro, de Sola-Llamas Carmen García, Ruvolo Michael, Vilches-Arenas Angel, Relimpio-López M Isabel, Espejo-Arjona Francisco, Macías-García Laura, De Miguel-Rodríguez Manuel, García-Escudero Antonio, Idoate Miguel A, Ríos-Martín Juan J

Abstract excerpt

BACKGROUND: Uveal melanoma (UM) is the eye's most common primary malignancy and there are no effective therapies for disseminated disease. It is important to try to know the patient's prognosis. The aim of this study was to reflect genetic variants, studied using NGS, of a series of 69 cases of UM and its correlation with histopathology and clinical progression. METHODS: We performed targeted NGS using a 519-gene...

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PMID: 37803816
DOI: 10.1111/ceo.14302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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