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Article

Cross-dataset transcriptomic analyses identify a conserved ENPP2+ macrophage-fibroblast activation axis in hypertrophic cardiomyopathy.

Briefings in bioinformatics - 7 Jan 2026

Huang Fanyi, Zhou Mi, Chen Yanjia, Hua Sha, Han Yanxin, Fan Yingze, Li Qingchuan, Sun Zhuoyan, Yang Ke, Zhao Qiang, Jin Wei

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a condition where approximately 65% of patients exhibit myocardial fibrosis, indicated by late gadolinium enhancement, with the severity and extent of fibrosis being positively correlated with the risk of sudden cardiac death. While fibroblast activation in HCM has been noted in previous studies, the underlying regulatory mechanisms have not been thoroughly explored. In this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41642196
DOI: 10.1093/bib/bbag036
PMCID: PMC12874883

Genes

ENPP2
COL14A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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