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Article

Treatment outcome according to genetic tumour alterations and clinical characteristics in digestive high-grade neuroendocrine neoplasms.

British journal of cancer - 1 Sept 2024

Elvebakken Hege, Venizelos Andreas, Perren Aurel, Couvelard Anne, Lothe Inger Marie B, Hjortland Geir O, Myklebust Tor Å, Svensson Johanna, Garresori Herish, Kersten Christian, Hofsli Eva, Detlefsen Sönke, Vestermark Lene W, Knappskog Stian, Sorbye Halfdan

Abstract excerpt

BACKGROUND: Chemotherapy has limited efficacy in advanced digestive high-grade neuroendocrine neoplasms (HG-NEN) and prognosis is dismal. Predictive markers for palliative chemotherapy are lacking, and prognostic markers are limited. METHODS: Digestive HG-NEN patients (n = 229) were prospectively included 2013-2017. Pathological re-assessment revealed 188 neuroendocrine carcinomas (NEC) and 41 neuroendocrine...

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Identifiers

PMID: 38909137
DOI: 10.1038/s41416-024-02773-w
PMCID: PMC11333587

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