Maladaptive somatic gene rescue as predisposition to JAK2 molecular abnormalities? Insights from an Israeli family.

Abstract excerpt

Eosinophilia associated with PCM1::JAK2 fusion and classic Philadelphia (Ph)-negative myeloproliferative neoplasms (MPN) are both clonal disorders caused by a dysregulation of the JAK2 signaling pathway. The myeloid neoplasm with t(8;9)(p22;p24.1) and PCM1::JAK2 rearrangement is now formally included among the myeloid/lymphoid neoplasms with eosinophilia (M/LN-eo) and tyrosine kinase fusion genes. To date, no...

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