Article
Patatin-Like Phospholipase Domain Containing 3 I148M Variant Affects Hepatocellular Carcinoma Recurrence After Liver Resection.
Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2026
Nakayama Yuki, Takeishi Kazuki, Itoh Shinji, Motomura Takashi, Toshima Takeo, Yugawa Kyohei, Tomiyama Takahiro, Tsutsui Yuriko, Toshida Katsuya, Ishikawa Takuma, Mita Junya, Kurihara Takeshi, Soto-Gutierrez Alejandro, Yoshizumi Tomoharu
Abstract excerpt
BACKGROUND: Patatin-like phospholipase domain 3 (PNPLA3) I148M (rs738409 C>G) variant has been reported as a risk factor for metabolic dysfunction-associated steatotic liver disease/steatohepatitis and contributes to hepatic fibrosis and hepatocellular carcinoma (HCC); however, its role in recurrence after liver resection remains unclear. This study aimed to evaluate the effect of PNPLA3 variants on HCC...
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