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Systematic review and meta-analysis of protocols and sequencing yield for whole genome sequencing of Mycobacterium tuberculosis directly from sputum samples.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2026

Mann B C, Loubser J, Omar S, Glanz C, Ektefaie Y, Jacobson K R, Warren R M, Farhat M R

Abstract excerpt

Direct sputum whole genome sequencing (dsWGS) can revolutionize Mycobacterium tuberculosis (Mtb) diagnosis by enabling rapid detection clinically relevant resistance mutations and strain diversity without the biohazard of culture. We searched PubMed, Web of Science, and Google Scholar, identifying 8 studies meeting inclusion criteria for testing protocols for dsWGS. Utilising meta-regression, we identified...

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Identifiers

PMID: 41633150
DOI: 10.1016/j.tube.2026.102743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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