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Article

Elevated homocysteine contributes to the progression of type 1 diabetic nephropathy: Evidence from Mendelian randomization and experimental validation.

Medicine - 30 Jan 2026

He Mingjie, Wen Jie, Zou Yan, Jiang Qiong, Zhong Aimin

Abstract excerpt

Hyperhomocysteinemia has been identified as a potential metabolic risk factor for type 1 diabetes-related nephropathy (T1DN). However, the causal relationship between homocysteine (Hcy) and T1DN remains unclear. We performed univariable Mendelian randomization (MR) and multivariable MR analyses to investigate the causal effects of Hcy and B vitamins (vitamin B6, B12, and folate) on T1DN in a cohort of 19,406...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41630263
DOI: 10.1097/MD.0000000000047341
PMCID: PMC12863804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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