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Article

A 5-year Chinese longitudinal case report on the malignant transformation of spinal Paget disease.

Medicine - 30 Jan 2026

Wang Yu, Zhang Linlin, Yang Huilin, Zhang Qin

Abstract excerpt

RATIONALE: Paget disease of bone (PDB) is a metabolic disorder typically regarded as benign, yet it carries a <1% risk of malignant transformation into osteosarcoma malignant transformation into osteosarcoma, particularly with spinal involvement. Differentiation from other aggressive spinal lesions can be challenging. In Asian populations, prognostic data on Paget sarcoma are scarce. The significance of dual...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41630218
DOI: 10.1097/MD.0000000000047190
PMCID: PMC12863807

Genes

SQSTM1
ZNF687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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