Genome-Wide Association Study Identifies Genetic Loci for Antibody Response to SARS-CoV-2 Vaccines in Patients With Systemic Autoimmune Diseases and Healthy Individuals.

doi:10.3899/jrheum.2025-0770

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Article

Genome-Wide Association Study Identifies Genetic Loci for Antibody Response to SARS-CoV-2 Vaccines in Patients With Systemic Autoimmune Diseases and Healthy Individuals.

The Journal of rheumatology - 1 Apr 2026

Kim Kwangwoo, Claybaugh Dillon, Patino-Martinez Eduardo, Temesgen-Oyelakin Yenealem, Poncio Elaine, Chu Jun, Davis Michael, Fike Alice, Ruiz-Perdomo Yanira, Onyechi Julie, Beach Margaret, Howard Lilian, Pelayo Eileen, Spencer Nancy, Sully Martha, Volochayev Rita, Kelly Sophie, Porche Sarah, Lewandowski Laura B, Franco Luis M, Manna Zerai, Gupta Sarthak, Hutchinson Amy, Mirabello Lisa, Vij Vibha, Quinn Kaitlin A, Grayson Peter C, Schiffenbauer Adam, Rider Lisa G, Pinal-Fernandez Iago, Mammen Andrew L, Kalish Heather R, Waldman Meryl A, Warner Blake, Hasni Sarfaraz, Chanock Stephen J, Kaplan Mariana J

Abstract excerpt

OBJECTIVE: The efficacy of nucleic acid-based vaccines against SARS-CoV-2 varies across individuals, partly due to genetic factors influencing neutralizing antibody production. In patients with systemic autoimmune diseases (SADs), this response may be further altered by immune dysregulation. METHODS: We conducted a genome-wide association study (GWAS) to identify genetic variants associated with postvaccination...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41621945
DOI: 10.3899/jrheum.2025-0770
PMCID: PMC12866942

Genes

RACGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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