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Article

Frailty phenotypes and determinants of glucocorticoid-related adverse events in polymyalgia rheumatica at 12 months: a real-life single-center investigation.

Clinical rheumatology - 1 Mar 2026

Hysa Elvis, Iandolino Nicola, Balito Serena, Mairone Gianluca, Gotelli Emanuele, Campitiello Rosanna, Pizzorni Carmen, Paolino Sabrina, Smith Vanessa, Sulli Alberto, Cutolo Maurizio

Abstract excerpt

BACKGROUND: Polymyalgia rheumatica (PMR) is a clinically heterogeneous disease with variable trajectories. Although glucocorticoids (GCs) are effective, prolonged exposure carries significant toxicity risks. This study was aimed at exploring whether baseline frailty phenotypes (stratified by age and comorbidity burden) and treatment exposure influenced relapse patterns and the occurrence of glucocorticoid-related...

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PMID: 41619157
DOI: 10.1007/s10067-026-07965-8

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