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Article

Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes

1 Mar 2020

Abstract excerpt

Brown adipose tissue (BAT) activity protects animals against hypothermia and represents a potential therapeutic target to combat obesity. The transcription factor early B cell factor-2 (EBF2) promotes brown adipocyte differentiation, but its roles in maintaining brown adipocyte fate and in stimulating BAT recruitment during cold exposure were unknown. We find that the deletion of Ebf2 in adipocytes of mice...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 32130892
DOI: 10.1016/j.celrep.2020.02.023

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