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SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice

14 Oct 2024

Abstract excerpt

Brown adipose tissue (BAT) is critical for non-shivering thermogenesis making it a promising therapeutic strategy to combat obesity and metabolic disease. However, the regulatory mechanisms underlying brown fat formation remain incompletely understood. Here, we found SOX4 is required for BAT development and thermogenic program. Depletion of SOX4 in BAT progenitors (Sox4-MKO) or brown adipocytes (Sox4-BKO)...

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PMID: 39402212
DOI: 10.1038/s41418-024-01397-0

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