Article
Shorter kidney telomeres are associated with nephrosclerosis by an epigenetic signature.
Cardiovascular research - 26 Mar 2026
Akinnibosun Olutope Arinola, Xu Xiaoguang, Emmett Amber, Nguyen Huy, Hames-Fathi Shadi, Drzal Maciej, Eales James, Scannali David, Prestes Priscilla R, Denniff Matthew, Bogdanski Pawel, Zywiec Joanna, Wystrychowski Wojciech, Zukowska-Szczechowska Ewa, Guzik Tomasz J, Samani Nilesh J, Dormer John, Tomaszewski Maciej, Charchar Fadi J
Abstract excerpt
AIMS: Ageing leads to a progressive loss in structural integrity and a functional decline of human organs, alongside telomere attrition and alterations in DNA methylation patterns. Their relationships in the human kidney in the context of ageing remain elusive. METHODS AND RESULTS: We analysed 200 participants from the human kidney tissue resource (HKTR) with matching information on kidney histology, renal...
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