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Article

Association of MMP9 and NOS3 Polymorphisms with Distinct Clinical Forms of Juvenile Scleroderma and Characteristics of Humoral Immunity.

International journal of molecular sciences - 22 Jan 2026

Osminina Maria, Podzolkova Vera, Litvinova Maria, Geppe Natalia, Chebysheva Svetlana, Khachatryan Lusine, Golovanova Natalia, Kostina Yulia, Lazareva-Batyreva Oksana, Polyanskaya Angelina, Shpitonkova Olga, Subbotina Tatiana, Areian Tigran, Podchernyaeva Nadezhda

Abstract excerpt

Juvenile scleroderma (JS), comprising localized (JLSd) and systemic (JSSc) forms, is a rare autoimmune disorder. This study investigated associations of polymorphisms in extracellular matrix (MMP1, MMP9) and vascular homeostasis (NOS3) genes with JS risk and immunological phenotypes. A case-control study involved 215JS patients (194 JLSd, 21 JSSc) and 72 controls. SNPs (MMP1 rs1799750, MMP9 rs3918242, NOS3...

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Source

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Identifiers

PMID: 41596747
DOI: 10.3390/ijms27021109
PMCID: PMC12841920

Genes

MMP9
NOS3
MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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