The role of the endothelial nitric oxide synthase variants in the development of juvenile idiopathic arthritis and its clinical findings.

doi:10.1590/1806-9282.20250835

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Article

The role of the endothelial nitric oxide synthase variants in the development of juvenile idiopathic arthritis and its clinical findings.

Revista da Associacao Medica Brasileira (1992) - 1 Jan 2026

Dogantan Seyda, Sayin Sevde Hasanoğlu, Yücel Burcu Bozkaya, Taskin Sema Nur, Qizi Khumara Vagif, Pehlivan Sacide

Abstract excerpt

OBJECTIVE: Juvenile idiopathic arthritis is the most common chronic arthritis in children and adolescents. Nitric oxide mediates autoimmune responses and plays a role in the etiology of numerous rheumatic diseases. Endothelial nitric oxide synthase regulates nitric oxide levels through catalyzing its production. Here, we evaluated the effect of eNOS rs1799983 and variable number tandem repeat variants on disease...

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PMID: 41919879
DOI: 10.1590/1806-9282.20250835
PMCID: PMC13035188

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