Article
HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap.
Rheumatology (Oxford, England) - 1 Dec 2007
Wedderburn L R, McHugh N J, Chinoy H, Cooper R G, Salway F, Ollier W E R, McCann L J, Varsani H, Dunphy J, North J, Davidson J E
Abstract excerpt
OBJECTIVES: To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those with JDM-scleroderma (JDM-SSc) overlap, using detailed serological analysis, HLA class II genotyping and clinical characterization. METHODS: Children (114) with JDM were recruited, and clinical data collected, through the JDM National Registry and Repository (UK and Ireland). Sera were assayed for ANA using...
Topics
- Autoantibodies
- Case-Control Studies
- Child
- Child, Preschool
- Dermatomyositis
- Diagnosis, Differential
- Female
- Fluorescent Antibody Technique, Indirect
- Genetic Predisposition to Disease
- Genotype