Article
Therapy with dendritic cells influences the spontaneous resorption rate in the CBA/J x DBA/2J mouse model.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Jan 2004
Blois Sandra, Alba Soto Catalina D, Olmos Sofia, Chuluyan Eduardo, Gentile Teresa, Arck Petra C, Margni Ricardo A
Abstract excerpt
PROBLEM: DBA/2J-mated CBA/J female mice are prone to a high incidence of fetal abortions. This fetal wastage can be dramatically reduced by immunizing the female mice with BALB/c, but not with DBA/2J spleen cells during early gestation. Nevertheless, the underlying mechanisms remain to be elucidated. Recently, dendritic cells (DC) have been described at the feto-maternal interface in the human uterus. In this...
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