Machine Learning Reveals Common Regulatory Mechanisms Mediated by Autophagy-Related Genes in the Development of Inflammatory Bowel Disease and Major Depressive Disorder.

Abstract excerpt

BACKGROUND: Major Depressive Disorder (MDD) is more common in patients with Inflammatory Bowel Disease (IBD) than in the general population, suggesting a shared but unclear pathogenesis. Autophagy, a conserved intracellular cleaning process, maintains cellular health by removing debris and recycling nutrients. Given the limited research on autophagy in this comorbidity, this study investigated the role of...

Topics

• Humans
• Machine Learning
• Major Depressive Disorder
• Autophagy
• Inflammatory Bowel Diseases
• Molecular Docking Simulation
• Genetic Predisposition to Disease
• Autophagy-Related Proteins