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Insights into the Pathophysiology of Scheuermann's Kyphosis: From Structural Deformities to Genetic Predisposition and Underlying Signalling Pathways.

Biomolecules - 30 Dec 2025

Kaspiris Angelos, Spyrou Ioannis, Marougklianis Vasileios, Afrati Spyridoula Roberta, Sakellariou Evangelos, Varsamos Iordanis, Karampinas Panagiotis, Vasiliadis Elias, Pneumaticos Spiros G

Abstract excerpt

Scheuermann's kyphosis (SK) is a rigid dorsal kyphosis of unclear pathophysiological origin. The aim of this review is to summarise current theories and both clinical and experimental findings regarding the underlying mechanisms of SK. Emerging evidence highlights the significant role of excessive mechanical loading as a major contributor to defective growth of the cartilaginous vertebral endplate. This is...

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PMID: 41594596
DOI: 10.3390/biom16010056
PMCID: PMC12839117

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