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Inherited genetic predisposition and imaging concordance in degenerative lumbar scoliosis patients and their descendants.

Journal of orthopaedic surgery and research - 21 Aug 2024

Shang Zhenguo, Liu Yilei, Yuan Hongru, Huo Yachong, Zhang Di, Li Weishi, Ding Wenyuan, Wang Hui

Abstract excerpt

BACKGROUND: Offspring consistently exhibit similar imaging features as their parents in cases of degenerative lumbar scoliosis (DLS). Nevertheless, the role of genetic factors in the pathogenesis of DLS remains uncertain. METHODS: A prospective analysis was conducted on 35 patients with DLS and their 36 offspring. Genomic DNA was extracted from 71 blood samples for gene mutation analysis using whole exome...

Topics

Humans
Scoliosis
Female
Genetic Predisposition to Disease
Male
Middle Aged
Lumbar Vertebrae
Prospective Studies
Aged
Pedigree
Mutation

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Adult

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PMID: 39169360
DOI: 10.1186/s13018-024-05000-7
PMCID: PMC11337562

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