Article

Oxidative stress induces intervertebral ECM remodelling, elevated tissue stiffness and idiopathic-like scoliosis

2024-09-09

Abstract excerpt

<title>Abstract</title> <p>Adolescent idiopathic scoliosis (AIS) is the most prevalent paediatric spine disorder, developing in the absence of obvious congenital or physiological defects. Patient genetic sequencing and mouse functional studies have demonstrated association of musculoskeletal collagen variants and cartilaginous extracellular matrix (ECM) defects in a subset of cases. However, the underlying biolog...

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Literature Corpus work: dd2910c6-8451-5bb7-a877-fad0dd0706dd
DOI: 10.21203/rs.3.rs-4978808/v1

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