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Non-Clear Cell Renal Cell Carcinoma Has an Immune-Cold Phenotype That Affects Response to Immune Checkpoint Inhibitors.

Molecular cancer research : MCR - 4 May 2026

Ishihara Hiroki, Liu Yu-Yu, Yamashita Riu, Fukuda Hironori, Mizoguchi Yukihiro, Yamashita Makiko, Kitano Shigehisa, Aoki Kazunori, Tachibana Hidekazu, Mizoguchi Shinsuke, Nishimura Koichi, Nakayama Takayuki, Nemoto Yuki, Yoshida Kazuhiko, Hirai Toshihito, Iizuka Junpei, Nagashima Yoji, Ushijima Toshikazu, Tokita Daisuke, Kondo Tsunenori, Takagi Toshio

Abstract excerpt

Data on the clinical outcomes of immune checkpoint inhibitor (ICI) therapy and tumor immune microenvironment (TIME) profiles in non-clear cell renal cell carcinoma (nccRCC) remain limited. In this study, we retrospectively compared the effectiveness profile of first-line ICI combination therapy between clear-cell renal cell carcinoma (ccRCC) and nccRCC. Additionally, genome-wide gene expression and...

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PMID: 41591388
DOI: 10.1158/1541-7786.MCR-25-0939

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