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Article

Inverted repeats in the monkeypox virus genome are hot spots for mutation.

Journal of medical virology - 1 Jan 2023

Dobrovolná Michaela, Brázda Václav, Warner Emily F, Bidula Stefan

Abstract excerpt

The current monkeypox virus (MPXV) strain differs from the strain arising in 2018 by 50+ single nucleotide polymorphisms (SNPs) and is mutating much faster than expected. The cytidine deaminase apolipoprotein B messenger RNA editing enzyme, catalytic subunit B (APOBEC3) was hypothesized to be driving this increased mutation. APOBEC has recently been identified to preferentially mutate cruciform DNA secondary...

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Identifiers

PMID: 36400742
DOI: 10.1002/jmv.28322
PMCID: PMC10100261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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