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Article

Rhodopsin molecular evolution from mouse to human phenylalanine 88 to leucine substitution enhances thermal stability and post-activation decay.

Scientific reports - 26 Jan 2026

Wang Feifei, Kolesnikov Alexander V, Sato Shinya, Singh Aneal, Makino Clint L, Garriga Pere, Kefalov Vladimir J

Abstract excerpt

The function of rod photoreceptors as dim light photon detectors depends critically on the molecular properties of their visual pigment, rhodopsin. The structure of rhodopsin has evolved under selective pressure to light conditions of different spectral composition and overall intensity. One notable example is the switch of mammalian species from nocturnal to diurnal environments. Comparison of the rhodopsins of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41588021
DOI: 10.1038/s41598-025-32531-8
PMCID: PMC12847716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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