Article
Comparative phenotypic analysis of rhodopsin supports stepwise evolution of dim-light vision in early vertebrates.
Molecular biology and evolution - 1 Apr 2026
Cui Yimeng, Lu Xiaoyang, Wei Peng, Shuai Mengqi, Sun Li, Xie Yaoqi, Xie Yanfang, Dong Ruijuan, Shi Leilei, Rossiter Stephen J, Xu Shixia, Liu Yang
Abstract excerpt
The origin of dim-light vision in vertebrates has been attributed to an early duplication event in an ancestral form of pigment called RH, which led to the formation of the RH1 (rhodopsin) and RH2 (rhodopsin-like) opsins. Two sites (122 and 189) are known to critically underlie rhodopsin's sensitivity in low light; however, the evolutionary trajectory leading to dim-light vision remains unclear. We built a large...
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