Article
Lower Rate of CTNNB1 Mutations and Higher Rate of APC Mutations in Desmoid Fibromatosis of the Breast: A Series of 134 Tumors.
The American journal of surgical pathology - 1 Sept 2020
Norkowski Emma, Masliah-Planchon Julien, Le Guellec Sophie, Trassard Martine, Courrèges Jean-Baptiste, Charron-Barra Céline, Terrier Philippe, Bonvalot Sylvie, Coindre Jean-Michel, Laé Marick
Abstract excerpt
Desmoid fibromatosis (DF) is a rare, locally aggressive, nonmetastasizing fibroblastic/myofibroblastic tumor with a tendency to recur and an unpredictable clinical course. A "wait-and-see" policy is the new standard of care. DF are characterized by activating alterations of the wnt/β-catenin pathway: CTNNB1 or adenomatous polyposis coli gene (APC) mutations (these mutations being mutually exclusive). Desmoid-type...
Topics
- Adenomatous Polyposis Coli Protein
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Breast Neoplasms
- Breast Neoplasms, Male
- Female
- Desmoid Tumors