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Lower Rate of CTNNB1 Mutations and Higher Rate of APC Mutations in Desmoid Fibromatosis of the Breast: A Series of 134 Tumors.

The American journal of surgical pathology - 1 Sept 2020

Norkowski Emma, Masliah-Planchon Julien, Le Guellec Sophie, Trassard Martine, Courrèges Jean-Baptiste, Charron-Barra Céline, Terrier Philippe, Bonvalot Sylvie, Coindre Jean-Michel, Laé Marick

Abstract excerpt

Desmoid fibromatosis (DF) is a rare, locally aggressive, nonmetastasizing fibroblastic/myofibroblastic tumor with a tendency to recur and an unpredictable clinical course. A "wait-and-see" policy is the new standard of care. DF are characterized by activating alterations of the wnt/β-catenin pathway: CTNNB1 or adenomatous polyposis coli gene (APC) mutations (these mutations being mutually exclusive). Desmoid-type...

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PMID: 32590455
DOI: 10.1097/PAS.0000000000001517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lower Rate of CTNNB1 Mutations and Higher Rate of APC Mutations in Desmoid Fibromatosis of the Breast: A Series of 134 Tumors.PMID 32590455Read ↗

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