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Article

Genome-wide association study identifies GAK and KLF12 associated with curve severity of adolescent idiopathic scoliosis.

PeerJ - 1 Jan 2026

Dai Zhicheng, Wu Zhichong, Xu Leilei, Feng Zhenhua, Qiu Yong, Zhu Zezhang

Abstract excerpt

Background: Genetic factors have been increasingly recognized as important contributors to the development and progression of adolescent idiopathic scoliosis (AIS). However, the genetic basis underlying AIS curve severity remains largely unclear. The objective of this study is to identify novel genetic variants associated with curve severity in AIS through a genome-wide association study (GWAS). Methods: In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Polymorphism, Single Nucleotide

Share to Protein Serine-Threonine Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 41584833
DOI: 10.7717/peerj.20638
PMCID: PMC12826036

Genes

KLF12
GAK
DST
NIPSNAP3A
SEZ6L
SMC2
ST8SIA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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