Article
Genetic variant of MIR4300HG is associated with progression of adolescent idiopathic scoliosis in a Chinese population.
Journal of orthopaedic surgery and research - 13 May 2021
Wang Yuwen, Dai Zhicheng, Wu Zhichong, Feng Zhenhua, Liu Zhen, Sun Xu, Xu Leilei, Qiu Yong, Zhu Zezhang
Abstract excerpt
BACKGROUND: A recent genome-wide association study identified a susceptible locus in MIR4300HG gene that was associated with curve progression of adolescent idiopathic scoliosis (AIS) in the Japanese population. However, the association between the gene and curve progression in other populations remains unclear. METHODS: A cohort of 1952 AIS patients and 2495 healthy controls were included in the case-control...
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