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Article

Clinical and genetic evidence from East Asian cohorts linking family history burden and menarche timing to curve severity in adolescent idiopathic scoliosis.

Frontiers in endocrinology - 1 Jan 2026

Tanaka Ryutaro, Iwami Takuro, Yonezawa Yoshiro, Otomo Nao, Takeda Kazuki, Ikegawa Shiro, Matsumoto Morio, Nakamura Masaya, Watanabe Kota, Terao Chikashi

Abstract excerpt

Introduction: Adolescent idiopathic scoliosis (AIS) affects 2% to 3% of adolescents and progresses rapidly during puberty. Previous studies suggest that a positive family history of AIS and a later age at menarche (AAM) are risk factors for curve severity in AIS, but their quantitative evidence and the causal contribution of AAM remain to be elucidated. Methods: We analyzed 5,891 patients with AIS to evaluate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42630198
DOI: 10.3389/fendo.2026.1876849
PMCID: PMC13493220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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