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Article

Modifiable Lifestyle Factors, Genetic Susceptibility, and Incident Radiographic Axial Spondyloarthritis.

The Journal of rheumatology - 1 Sept 2025

Liu Ke, Lin Hao, Ying Jiacheng, Luo Peiyang, Wang Manli, He Zhixing, Ye Ding, Wei James Cheng-Chung, Mao Yingying

Abstract excerpt

OBJECTIVE: To evaluate modifiable lifestyle-genetic susceptibility interactions with the risk of developing radiographic axial spondyloarthritis (r-axSpA). METHODS: This study included 382,035 individuals without r-axSpA at baseline in the UK Biobank. A combined lifestyle score consisting of 6 factors and a polygenic risk score (PRS) using r-axSpA-associated genetic loci was constructed for each participant....

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PMID: 40518179
DOI: 10.3899/jrheum.2025-0042

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