Article
The diagnostic value of cortical high-flow sign combined with cystathionine on 1H-MRS for prediction of 1p/19q-codeletion status in IDH-mutant adult-type diffuse glioma.
Neuroradiology - 1 Feb 2026
Yamashita Koji, Tomiyasu Moyoko, Kikuchi Kazufumi, Momosaka Daichi, Kusunoki Masaoki, Kuga Daisuke, Hatae Ryusuke, Fujioka Yutaka, Otsuji Ryosuke, Togao Osamu, Yoshimoto Koji, Ishigami Kousei
Abstract excerpt
OBJECTIVES: To leverage a combination of cortical high-flow sign on arterial spin labeling (ASL) and cystathionine measurement using 1H-MR spectroscopy (1H-MRS) to distinguish oligodendroglioma, IDH-mutant and 1p/19q-codeleted (O_IDHm-codel) from astrocytoma, IDH-mutant (A_IDHm-noncodel). MATERIALS AND METHODS: We implemented pseudo-continuous ASL technique (post-labeling delay = 2000 ms) using a 3.0-T MRI...
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