Dual Sub‑MIC Copper-Gentamicin Stress Drives Strain‑Specific, Non‑Additive Phenotypic Shifts in Pseudomonas aeruginosa.

Abstract excerpt

Exposure to redox‑active metals and sub‑inhibitory antibiotics represents a significant selective pressure shaping bacterial physiology and antimicrobial susceptibility. Here, we investigated how four genetically and phenotypically distinct Pseudomonas aeruginosa strains respond to sub‑MIC copper (Cu) and gentamicin (GE) stress, individually and in combination (Cu + GE). Across all strains, Cu acted as the...

Topics

• Copper
• Pseudomonas aeruginosa
• Gentamicins
• Anti-Bacterial Agents
• Phenotype
• Stress, Physiological