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Article

Biallelic NF1 Inactivation and Widespread Loss of Heterozygosity in a Subset of Unclassified Fibromyxoid Mesenchymal Neoplasms.

Genes, chromosomes & cancer - 1 Jan 2026

Saoud Carla, Agaram Narasimhan, Singer Samuel, Villafania Liliana B, Benhamida Jamal, Antonescu Cristina R

Abstract excerpt

The integration of next generation sequencing into clinical practice has revolutionized the diagnosis of soft tissue tumors, enabling the discovery of novel tumor entities. We encountered a group of unclassified fibromyxoid mesenchymal neoplasms harboring biallelic NF1 loss of function (LOF) mutations, lacking features of neurofibroma or neurofibromatosis. The tumors were investigated by immunohistochemistry...

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Identifiers

PMID: 41568893
DOI: 10.1002/gcc.70109

Genes

NF1
CD34

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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