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Article

Microenvironment-Guided Evolution of ssDNA-SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Mar 2026

Lee Dakyeon, Lee Seok-Hyeon, Jung Yunseo, Lee Jeongho, Choi Min-Seo, Oh SaeOck, Kim Sungjee, Kim Byoung Soo, Jeong Sanghwa

Abstract excerpt

Despite advances in prostate cancer detection, distinguishing indolent from aggressive phenotypes remains challenging. We report a microenvironment-guided strategy for evolving phenotype-specific molecular probes using single-stranded DNA-functionalized single-walled carbon nanotubes (ssDNA-SWCNTs). Our approach employs 3D tumor models that recapitulate complex cancer microenvironments, enabling identification of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41566610
DOI: 10.1002/advs.202518582
PMCID: PMC13042387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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