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A genome-wide genetic screen reveals the P2Y2-integrin axis as a stabilizer of EGFR mutants in non-small cell lung cancer (NSCLC).

Science advances - 23 Jan 2026

Du Yafei, Wang Wenjing, Goh Hui Chin, Vaiyapuri Thamil Selvan, Raju Anandhkumar, Hsiao Yu-Chun, Wang Cheng Chun, Agrawal Vanisha, Mohideen Noorul Farzana, Mohd Mazian Norhidayah Binte, Karatekin Feride, Wang Wendy Kehan, Lakshmanan Manikandan, Gupta Komal, Chang Han, Le Guezennec Xavier, Bard Frederic, Tan Daniel S W, Tergaonkar Vinay, Hung Mien-Chie, Liu Xiaogang, Hong Wanjin, Boopathy Gandhi T K

Abstract excerpt

Activating mutations in the epidermal growth factor receptor (EGFR) gene drive non-small cell lung cancer (NSCLC). Oncogenic EGFR mutants are ligand-independent and more stable, but the underlying mechanism remains unclear. We hypothesized that EGFR mutants selectively leverage cellular stabilizers to evade degradation. Genome-wide RNA interference screens identified genes (encoding for stabilizers) responsible...

Topics

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Adenosine Triphosphate
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

RNA Interference

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Open in PubMed Open full text

Identifiers

PMID: 41564171
DOI: 10.1126/sciadv.adv3980
PMCID: PMC12822653

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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