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Article

Pericytes Modulate Third-Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR-Mutated Lung Cancer Cells Through IL32-β5-Integrin Paracrine Signaling.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Dec 2024

Huang Cheng, Huang Xi, Qiu Xiaoyi, Kong Xiangzhan, Wu Chunmiao, Jiang Xue, Yao Mingkang, Wang Minghui, Su Liangping, Lv Cui, Wong Ping-Pui

Abstract excerpt

EGFR-mutated lung cancer patients sometimes display restricted responses to third-generation tyrosine kinase inhibitors (TKIs), potentially attributable to undervalued input from stromal cells, notably pericytes (PCs). The study shows that PCs isolated from EGFR-mutated patients have a unique secretome profile, notably secreting IL32 and affecting signaling pathways and biological processes linked to TKI...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39435643
DOI: 10.1002/advs.202405130
PMCID: PMC11633494

Genes

EGFR
IL32
YY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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