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Article

Tumor mutation burden as a biomarker in resected gastric cancer via its association with immune infiltration and hypoxia.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jul 2021

Wang Deqiang, Wang Ning, Li Xiaoqin, Chen Xiaofeng, Shen Bo, Zhu Dongqin, Zhu Liuqing, Xu Yaping, Yu Yangyang, Shu Yongqian

Abstract excerpt

BACKGROUND: Tumor mutation burden (TMB) predicts immunotherapy efficacy in solid tumors. However, the biomarker role of TMB is still conflicting in resected tumors. We aimed to examine the association of TMB with prognosis and postoperative chemotherapy (CT) or radiochemotherapy (RCT) efficacy in resected gastric cancer (GC). METHODS: Whole-exome sequencing (WES) was performed in 73 resected GC specimens....

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PMID: 33687617
DOI: 10.1007/s10120-021-01175-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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