Article
In Utero and Early-Life Exposure to Tobacco Smoke, Genetic Risk, and Chronic Obstructive Pulmonary Disease Incidence in Adulthood.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 22 May 2026
Deng Yao, Geng Xuyang, Lin Zefang, Yang Mingqi, Lin Qiuping, Zheng Zhixiong, Su Wen, Zhan Meixiao, Chen Liangkai, Sun Taoping, Liu Mubiao
Abstract excerpt
INTRODUCTION: This study aimed to evaluate whether in utero and early-life tobacco exposure and genetic factors jointly contribute to incident chronic obstructive pulmonary disease (COPD). METHODS: A total of 412 050 participants without COPD at baseline were included. We assessed the associations of in utero tobacco exposure, age of smoking initiation, and their interactions with joint COPD polygenic risk scores...
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