Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GSTO1 as a Potential Risk Factor for Diabetic Nephropathy: Evidence From Mendelian Randomisation and Multi-Omics Analyses.

Nephrology (Carlton, Vic.) - 1 Jan 2026

Tan Jiang, Lei Sisi, Zhao Liang, Hu Jiliang, Chen Yuqin

Abstract excerpt

AIM: Diabetic nephropathy (DN) is a major complication of diabetes mellitus and a leading cause of end-stage renal disease (ESRD). Glutathione S-transferase omega 1 (GSTO1) is implicated in redox regulation and inflammation, but its causal role in DN remains unclear. This study aimed to investigate the potential causal relationship between GSTO1 and DN risk. METHODS: Two-sample Mendelian randomisation (MR)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Diabetic Nephropathies
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Mendelian Randomization Analysis

Share to Multiomics

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Identifiers

PMID: 41549440
DOI: 10.1111/nep.70165

Genes

GSTO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GSTO1 as a Potential Risk Factor for Diabetic Nephropathy: Evidence From Mendelian Randomisation and Multi-Omics Analyses.PMID 41549440Read ↗

Effects of genetic polymorphisms of glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) on the risk of diabetic nephropathy: a meta-analysis.Semantic proximity Read ↗

The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk.Semantic proximity Read ↗

The Genetics of Diabetic NephropathySemantic proximity Read ↗

Identification of diagnostic biomarkers for diabetes nephropathy by multi-chip integrated bioinformatics combining machine-learning strategies and mendelian randomizationSemantic proximity Read ↗

The Susceptibility Genes in Diabetic NephropathySemantic proximity Read ↗

Identification of hub genes involved in the pathogenesis of diabetic nephropathy: A multi‐omics study integrating machine learning, mendelian randomization and mediation analysisSemantic proximity Read ↗

Integrative multi-omics Mendelian randomization reveals key lipid metabolism genes as therapeutic targets for diabetic nephropathy pathogenesis.Semantic proximity Read ↗

Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population.Semantic proximity Read ↗

Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy.Semantic proximity Read ↗

Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease.Semantic proximity Read ↗

Causal relationships of lipid metabolism in diabetic nephropathy risk: A two-sample Mendelian randomization study.Semantic proximity Read ↗

Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.