Article
A method for generation phage cocktail with great therapeutic potential.
PloS one - 1 Jan 2012
Gu Jingmin, Liu Xiaohe, Li Yue, Han Wenyu, Lei Liancheng, Yang Yongjun, Zhao Honglei, Gao Yu, Song Jun, Lu Rong, Sun Changjiang, Feng Xin
Abstract excerpt
BACKGROUND: Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant variants after phage treatment limited its therapeutic application. METHODOLOGY/PRINCIPAL FINDINGS: In this study, an approach, named "Step-by-Step" (SBS), has been established. This method takes advantage of the occurrence of phage-resistant bacteria...
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