A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe.

doi:10.1016/j.meegid.2015.02.001

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Article

A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2015

Donoghue Helen D, Michael Taylor G, Marcsik Antónia, Molnár Erika, Pálfi Gyorgy, Pap Ildikó, Teschler-Nicola Maria, Pinhasi Ron, Erdal Yilmaz S, Velemínsky Petr, Likovsky Jakub, Belcastro Maria Giovanna, Mariotti Valentina, Riga Alessandro, Rubini Mauro, Zaio Paola, Besra Gurdyal S, Lee Oona Y-C, Wu Houdini H T, Minnikin David E, Bull Ian D, O'Grady Justin, Spigelman Mark

Abstract excerpt

Leprosy was rare in Europe during the Roman period, yet its prevalence increased dramatically in medieval times. We examined human remains, with paleopathological lesions indicative of leprosy, dated to the 6th-11th century AD, from Central and Eastern Europe and Byzantine Anatolia. Analysis of ancient DNA and bacterial cell wall lipid biomarkers revealed Mycobacterium leprae in skeletal remains from 6th-8th...

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PMID: 25680828
DOI: 10.1016/j.meegid.2015.02.001

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