Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.

doi:10.1371/journal.ppat.1006997

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Article

Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.

PLoS pathogens - 1 May 2018

Schuenemann Verena J, Avanzi Charlotte, Krause-Kyora Ben, Seitz Alexander, Herbig Alexander, Inskip Sarah, Bonazzi Marion, Reiter Ella, Urban Christian, Dangvard Pedersen Dorthe, Taylor G Michael, Singh Pushpendra, Stewart Graham R, Velemínský Petr, Likovsky Jakub, Marcsik Antónia, Molnár Erika, Pálfi György, Mariotti Valentina, Riga Alessandro, Belcastro M Giovanna, Boldsen Jesper L, Nebel Almut, Mays Simon, Donoghue Helen D, Zakrzewski Sonia, Benjak Andrej, Nieselt Kay, Cole Stewart T, Krause Johannes

Abstract excerpt

Studying ancient DNA allows us to retrace the evolutionary history of human pathogens, such as Mycobacterium leprae, the main causative agent of leprosy. Leprosy is one of the oldest recorded and most stigmatizing diseases in human history. The disease was prevalent in Europe until the 16th century and is still endemic in many countries with over 200,000 new cases reported annually. Previous worldwide studies on...

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PMID: 29746563
DOI: 10.1371/journal.ppat.1006997
PMCID: PMC5944922

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