Article
Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C.
Journal of the American Heart Association - 15 Mar 2016
Taylor Erik N, Hoffman Matthew P, Barefield David Y, Aninwene George E, Abrishamchi Aurash D, Lynch Thomas L, Govindan Suresh, Osinska Hanna, Robbins Jeffrey, Sadayappan Sakthivel, Gilbert Richard J
Abstract excerpt
BACKGROUND: The geometric organization of myocytes in the ventricular wall comprises the structural underpinnings of cardiac mechanical function. Cardiac myosin binding protein-C (MYBPC3) is a sarcomeric protein, for which phosphorylation modulates myofilament binding, sarcomere morphology, and myocyte alignment in the ventricular wall. To elucidate the mechanisms by which MYBPC3 phospho-regulation affects...
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